Pharmacological characteristics of the direct oral anticoagulants
| Characteristics | Thrombin inhibitor | Factor Xa inhibitors | ||
| Dabigatran | Apixaban | Edoxaban | Rivaroxaban | |
| Prodrug | Yes | No | No | No |
| Bioavailability | 3–7% | 50% | 62% | 80% |
| Time to peak concentration h | 1–3 | 1–3 | 1–3 | 2–4 |
| Half-life h | 12–17 | 8–15 | 8–10 | 7–13 |
| Renal clearance | 80% | 25% | 35% | 66% |
| Metabolism | P-glycoprotein | P-glycoprotein, CYP3A4 | P-glycoprotein, CYP3A4 | P-glycoprotein, CYP3A4 |
CYP: cytochrome P450.