When Sjögren's syndrome is known, ILD screening should be systematic | When ILD is known, Sjögren's syndrome screening must be systematic |
Investigate respiratory symptoms (dyspnoea, cough, crackles and squeaks, clubbing) Exclude an infectious, medication (www.pneumotox.com) or cardiovascular cause Confirm ILD by performing chest computed tomography Consultation with a lung specialist to discuss bronchoscopy with BAL, histological sampling (transbronchial and surgical biopsy) and therapeutic care | Investigate extra-respiratory symptoms suggestive of Sjögren's syndrome (keratoconjunctivitis sicca, swelling of the salivary glands or hyposialia, arthritis, arthralgia), perform a minor salivary gland biopsy and do a urine analysis Investigate antinuclear antibodies, rheumatoid factor, SSA/Ro and SSB/La, and perform serum protein electrophoresis Exclude another connective tissue disease Confirm dry eyes and dry mouth |
Consult a connective tissue disease expert to discuss therapeutic care |
ILD: interstitial lung disease; BAL: bronchoalveolar lavage.