Stage 1 eligibility criteria

Inclusion criteriaExclusion criteria
Sputum smear positive for Mycobacterium tuberculosisEvidence of pre-XDR-TB or XDR-TB
Extrapulmonary TB
Rifampicin resistance on line probe assay or culture-based drug susceptibility testingHas a critical illness or any condition that the investigator feels makes participation unsafe
Willing to have HIV test or be treated with antiretroviral treatment if HIV positiveIs pregnant or breastfeeding
Willing to use effective contraception if indicatedIs unlikely to be compliant to treatment or unable to take oral medication
Has a prolonged QTcF (>500 ms)
  • XDR: extensively drug-resistant; TB: tuberculosis; QTcF: Fridericia-corrected QT.