Sensitivity % (95% CI) | Specificity % (95% CI) | LR+ (95% CI) | LR− (95% CI) | Unselected# | High risk¶ | |||
Positive post-test probability % | Negative post-test probability % | Positive post-test probability % | Negative post-test probability % | |||||
Age 6 years asthma diagnosis | ||||||||
Year 1 | 11 (4.2–19) | 98 (96–100) | 6.1 (1.8–21) | 0.90 (0.83–0.98) | 43 | 10 | 73 | 28 |
Year 2 | 12 (4.2–19) | 99 (98–100) | 14 (2.6–80) | 0.89 (0.82–0.97) | 64 | 10 | 86 | 28 |
Year 3 | 17 (8.4–25) | 99 (98–100) | 21 (4.0–112) | 0.84 (0.75–0.93) | 72 | 9 | 90 | 2 |
Age 8 years asthma diagnosis | ||||||||
Year 1 | 8.2 (2.2–14) | 98 (97–100) | 5.3 (1.3–22) | 0.93 (0.87–1.0) | 40 | 10 | 69 | 29 |
Year 2 | 11 (3.9–18) | 99 (98–100) | 12 (2.1–64) | 0.90 (0.83–0.97) | 59 | 10 | 83 | 28 |
Year 3 | 19 (8.8–25) | 100 (99–100) | 55 (3.3–913) | 0.83 (0.75–0.92) | 87 | 9 | 96 | 26 |
Age 11 years asthma diagnosis | ||||||||
Year 1 | 11 (3.6–18) | 98 (95–100) | 4.9 (1.4–17) | 0.91 (0.83–1.0) | 38 | 10 | 68 | 28 |
Year 2 | 11 (3.6–19) | 98 (96–100) | 6.8 (1.7–28) | 0.90 (0.83–0.98) | 46 | 10 | 75 | 28 |
Year 3 | 19 (9.3–28) | 99 (97–100) | 19 (3.6–100) | 0.82 (0.73–0.92) | 70 | 9 | 89 | 26 |
#: 11% theoretical unselected population pre-test probability of asthma; ¶: 30% high-risk Childhood Origins of Asthma population pre-test probability of asthma. Reproduced and modified from [20] with permission from the publisher.