Adverse events reported in randomised controlled trials (RCTs) after administration of N-acetylcysteine (NAC) at low and high doses

 NAC dose
Gastrointestinal disorders
 Gastrointestinal pain41
 Epigastric discomfort31
 Loss of appetite10
 GORD symptoms01
 Dry mouth01
 Unpleasant taste10
Respiratory disorders
 Respiratory tract infection11
Other disorders
 Joint pain and muscle pain02
 Skin disorders10
 CNS disorders10
 Weight gain10
  • Data are presented as n. GORD: Gastro-oesophageal reflux disease; CNS: central nervous system.