TABLE 2

Results from a family-based study to determine the risk of chronic obstructive pulmonary disease in PI*MM and PI*MZ individuals

Genotypep-value
PI*MM#PI*MZ
FEV1/FVC
 Never-smoker0.81 (0.75–0.85)0.77 (0.73–0.83)ns
 Ever-smoker0.77 (0.72–0.81)0.71 (0.58–0.77)0.0013
FEV1 % predicted
 Never-smoker101.3 (88.7–110.6)102.2 (88.3–108.4)ns
 Ever-smoker94.8 (82.1–102.4)82.3 (63.1–94.4)0.0009
FEF25–75% % predicted
 Never-smoker84.1 (70.7–100.8)76.1 (63.6–99.4)ns
 Ever-smoker64.8 (52.2–90.2)47.7 (22.7–66.8)0.0002
  • Data are presented as median (interquartile range). FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; FEF25–75%: forced expiratory flow at 25–75% of FVC; ns: nonsignificant. #: n=99; : n=89. Reproduced from [13] with permission from the publisher.