Results from a family-based study to determine the risk of chronic obstructive pulmonary disease in PI*MM and PI*MZ individuals
| Genotype | p-value | ||
| PI*MM# | PI*MZ¶ | ||
| FEV1/FVC | |||
| Never-smoker | 0.81 (0.75–0.85) | 0.77 (0.73–0.83) | ns |
| Ever-smoker | 0.77 (0.72–0.81) | 0.71 (0.58–0.77) | 0.0013 |
| FEV1 % predicted | |||
| Never-smoker | 101.3 (88.7–110.6) | 102.2 (88.3–108.4) | ns |
| Ever-smoker | 94.8 (82.1–102.4) | 82.3 (63.1–94.4) | 0.0009 |
| FEF25–75% % predicted | |||
| Never-smoker | 84.1 (70.7–100.8) | 76.1 (63.6–99.4) | ns |
| Ever-smoker | 64.8 (52.2–90.2) | 47.7 (22.7–66.8) | 0.0002 |
Data are presented as median (interquartile range). FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; FEF25–75%: forced expiratory flow at 25–75% of FVC; ns: nonsignificant. #: n=99; ¶: n=89. Reproduced from [13] with permission from the publisher.