Proposed criteria for myositis associated with anti-tRNA synthetase antibody

Features the patient must have
Positive serological tests for an anti-tRNA synthetase antibody
Plus one major involvement:
 Evidence of overt or hypomyopathic myositis (elevated CPK levels, myalgia, proximal muscular weakness, positive muscular biopsy, electromyographic triad of myositis or MRI muscular oedema)
 Evidence of ILD according to ATS criteria
 Evidence of articular involvement (symmetrical inflammatory arthralgia or overt arthritis)
Or two minor involvements:
 Unexplained persistent fever
 Raynaud's phenomenon
 Mechanic's hands
  • CPK: creatine phosphokinase; MRI: magnetic resonance imaging; ILD: interstitial lung disease; ATS: American Thoracic Society. Reproduced and modified from [51], with permission from the publisher.