TABLE 2

Estimated α1-antitrypsin (AAT) deficiency PI*S and PI*Z gene frequency in 1203 patients with chronic obstructive pulmonary disease referred to targeted screening within the central Eastern European Alpha-1 Antitrypsin Network programme: 2013 to June 2014

Estimated AAT genotype frequency
PI*SPI*Z
Bulgaria20.3 (−2.4–43)
Lithuania47.6 (−16.8–112)
Poland19.2 (11.3–27.2)47.2 (34.9–59.5)
Romania19.6 (9.7–29.4)14.4 (5.9–22.8)
Slovakia13.1 (0.3–25.8)13.1 (0.3–25.8)
Mean17.9 (11.6–24.1)30.6 (22.5–38.7)
  • Data are presented as frequency (95% CI). Frequency was calculated as 1/Hardy–Weinberg. Data from [18].