Table 2. Evolving diagnostic criteria for allergic bronchopulmonary asperillosis (ABPA)
Rosenberg–Patterson criteria [73,#74]
    Major criteria
        Asthma
        Presence of transient pulmonary infiltrates (fleeting shadows)
        Immediate cutaneous reactivity to Aspergillus fumigatus
        Elevated total serum IgE
        Precipitating antibodies against A. fumigatus
        Peripheral blood eosinophilia
        Elevated serum IgE and IgG to A. fumigatus
        Central/proximal bronchiectasis with normal tapering of distal bronchi
    Minor criteria
        Expectoration of golden brownish sputum plugs
        Positive sputum culture for Aspergillus species
        Late (Arthus type) skin reactivity to A. fumigatus
Minimal essential criteria [19]
    Asthma
    Immediate cutaneous reactivity to A. fumigatus
    Total serum IgE >1000 ng·mL−1 (417 kU·L−1)
    Elevated specific IgE-/IgG to A. fumigatus
    Central bronchiectasis in the absence of distal bronchiectasis
Truly minimal criteria [18]
    Asthma
    Immediate cutaneous reactivity to A. fumigatus
    Total serum IgE >1000 ng·mL−1 (417 kU·L−1)
    Central bronchiectasis in the absence of distal bronchiectasis
ISHAM working group [68]
    Predisposing conditions
        Bronchial asthma
        Cystic fibrosis
    Obligatory criteria (both should be present)
        Type I Aspergillus skin test positive (immediate cutaneous hypersensitivity to Aspergillus antigen) or elevated IgE levels against A. fumigatus
        Elevated total IgE levels (>1000 IU·mL−1)#
    Other criteria (at least two of three)
        Presence of precipitating or IgG antibodies against A. fumigatus in serum
        Radiographic pulmonary opacities consistent with ABPA
        Total eosinophil count >500 cells·μL−1 in steroid naïve patients (may be historical)
  • ISHAM: International Society for Human and Animal Mycology. #: if the patient meets all other criteria an IgE value <1000 IU·mL−1 may be acceptable.