Table 1. Diagnostic right heart catheterisation parameters of patients meeting traditional haemodynamic criteria in the REVEAL registry by World Health Organization (WHO) group I diagnosis at enrolment
CharacteristicsAll patients#IPAHAll patients with APAHAPAH subgroups+
CHDCVD/CTDPortal hypertensionDrugs/
toxins
Subjects n252511661280250639136134
P̄pa mmHg50.7±13.652.1±13.049.1±13.859.5±16.944.9±11.248.5±10.652.2±12.2
    Subjects n252511661280250639136134
    p-value<0.001ƒ
Ppcw mmHg9.1±3.59.2±3.59.0±3.58.9±3.68.9±3.59.3±3.69.2±3.6
    Subjects n252511661280250639136134
    p-value0.14
P̄ra mmHg9.3±5.69.9±5.78.6±5.57.2±4.58.7±5.68.3±5.910.7±5.9
    Subjects n229810501174229580131127
    p-value<0.001ƒ
PVRI Wood units·m221.1±12.522.9±11.419.0±13.023.7±20.916.9±9.115.7±7.224.2±12.7
    Subjects n1868842965186488100100
    p-value<0.001ƒ
Fick or thermodilution CI L·min−1·m2§2.4±0.82.2±0.82.5±0.92.7±1.02.5±0.82.8±0.82.1±0.8
    Subjects n1868842965186488100100
    p-value<0.001ƒ
SV,O2 %62.9±10.061.8±9.864.2±10.167.3±9.563.3±10.066.6±8.561.1±9.7
    Subjects n14566657381483568696
    p-value<0.001ƒ

  • Data are presented as mean±sd, unless otherwise stated. PAH: pulmonary arterial hypertension; IPAH: idiopathic PAH; APAH: associated PAH; CHD: congenital heart disease; CVD/CTD: collagen vascular disease/connective tissue disease; P̄pa: mean pulmonary artery pressure; Ppcw: pulmonary capillary wedge pressure; P̄ra: mean right atrial pressure; PVRI: pulmonary vascular resistance index; CI: cardiac index; SV,O2: mixed venous oxygen saturation. #: all patients aged ≥19 yrs at diagnosis with a Ppcw ≤15 mmHg enrolled during the consecutive screening of newly and previously diagnosed patients, including those with WHO group I diagnoses other than IPAH or APAH (i.e. familial PAH, pulmonary veno-occulsive disease and persistent pulmonary hypertension of the newborn); : all APAH patients, including those with associated PAH subgroups other than CHD, CVD/CTD, portal hypertension, and drugs/toxins (i.e. HIV and others); +: APAH subgroups are mutually exclusive according to the following hierarchy for patients with multiple associated-PAH diagnoses: CHD, CVD/CTD, portal hypertension, drugs/toxins, HIV and others; §: the Fick CI is used unless it is missing, in which case thermodilution CI is used; ƒ: p-value for all haemodynamic parameters is obtained from the two-sample t-test examining the difference in the distribution of the characteristics among patients diagnosed with IPAH versus all patients with APAH. Reproduced from [15] with permission from the publisher.