Table 2. Examples of studies where fibrocytes have been detected in heart and lung disease
BloodQuantification of circulating fibrocytes may allow prediction of early mortality in patients with IPF[21]
BloodIncreased circulating fibrocyte levels correlate with the development of BOS after lung transplantation[23]
BloodThe number of circulating fibrocytes was significantly increased in all patients with ILD[22]
BloodFibrocytes are associated with the presence and extent of left ventricular hypertrophy in patients with hypertensive heart disease[20]
BloodPROFILE study ongoing[43]
BALBAL >6% provides an additive prognostic value to clinical predictors and may be useful to identify patients with acute lung injury and ARDS at highest risk of an adverse outcome[46]
BALFibrocytes were detected in BAL fluid in ∼50% of the patients with IPF and SSc-ILD. Their number was associated with less severe disease in IPF patients[47]
  • BAL: bronchoalveolar lavage; IPF: idiopathic pulmonary fibrosis; BOS: bronchiolitis obliterans syndrome; ILD: interstitial lung disease; ARDS: acute respiratory distress syndrome; SSc: systemic sclerosis.