Table 2. Examples of studies where fibrocytes have been detected in heart and lung disease

Sample	Outcome	[Ref.]
Blood	Quantification of circulating fibrocytes may allow prediction of early mortality in patients with IPF	[21]
Blood	Increased circulating fibrocyte levels correlate with the development of BOS after lung transplantation	[23]
Blood	The number of circulating fibrocytes was significantly increased in all patients with ILD	[22]
Blood	Fibrocytes are associated with the presence and extent of left ventricular hypertrophy in patients with hypertensive heart disease	[20]
Blood	PROFILE study ongoing	[43]
BAL	BAL >6% provides an additive prognostic value to clinical predictors and may be useful to identify patients with acute lung injury and ARDS at highest risk of an adverse outcome	[46]
BAL	Fibrocytes were detected in BAL fluid in ∼50% of the patients with IPF and SSc-ILD. Their number was associated with less severe disease in IPF patients	[47]

BAL: bronchoalveolar lavage; IPF: idiopathic pulmonary fibrosis; BOS: bronchiolitis obliterans syndrome; ILD: interstitial lung disease; ARDS: acute respiratory distress syndrome; SSc: systemic sclerosis.