PFT with DLCO |
Transthoracic echocardiogram |
NT-proBNP |
DETECT algorithm if DLCO <60% pred and >3 years disease duration |
Frequency of noninvasive tests: |
Transthoracic echocardiogram on annual basis as a screening test |
Transthoracic echocardiogram if new signs or symptoms develop |
PFT with DLCO on annual basis as a screening test |
PFT with DLCO if new signs or symptoms develop |
NT-proBNP if new signs of symptoms develop |
PFT: pulmonary function test; DLCO: diffusing capacity of the lung for carbon monoxide; NT-proBNP: N-terminal pro-brain natriuretic peptide; % pred: % predicted. Reproduced with modification from [50] with permission from the publisher.