Drug | Mechanism of Action | |
IFIGENIA [20] | NAC | Antioxidant |
PANTHER-IPF [21] | Prednisone Azathioprine NAC | Antioxidant Immunosuppression |
Taniguchi [22] | Pirfenidone | Antifibrotic |
CAPACITY 1 [23] | Pirfenidone | Antifibrotic |
CAPACITY 2 [23] | Pirfenidone | Antifibrotic |
ACE-IPF [24] | Warfarin | Anticoagulant |
TOMORROW [25] | BIBF 1120 | Tyrosine-kinase inhibitor |
Daniels [26] | Imatinib mesylate | Tyrosine-kinase inhibitor |
STEP-IPF [27] | Sildenafil | Phosphodiesterase-5 inhibitor |
BUILD-1 [28] | Bosentan | Endothelin-receptor antagonist |
BUILD-3 [29] | Bosentan | Endothelin-receptor antagonist |
ARTEMIS-IPF [30] | Ambrisentan | Endothelin-receptor antagonist |
MUSIC-IPF [31] | Macitentan | Endothelin-receptor antagonist |
Raghu [32] | IFN-γ | Immunomodulation |
INSPIRE [33] | IFN-γ | Immunomodulation |
NAC: N-acetyl-cysteine; IFN: interferon.