| UCTD diagnostic criteria# | Broader definition of UCTD#,¶ | |
| A. Symptoms associated with CTD | At least one of: 1) Raynaud’s phenomenon; 2) arthralgias/multiple joint swelling; 3) morning stiffness; 4) dry mouth or dry eyes (Sicca features); 5) proximal muscle weakness | At least one of: 1) Raynaud’s phenomenon; 2) arthralgias/multiple joint swelling; 3) photosensitivity; 4) unintentional weight loss; 5) morning stiffness; 6) dry mouth or dry eyes (Sicca features); 7) dysphagia; 8) recurrent unexplained fever; 9) gastro-oesophageal reflux; 10) skin changes (rash); 11) oral ulceration; 12) nonandrogenic alopecia; 13) proximal muscle weakness |
| B. Positive autoimmune serology | Positive finding of at least one of: 1) ANA (high titre); 2) RF (high titre); 3) positive ENA; 4) anti-Scl70 antibody; 5) anti-RNP antibody; 6) anticentromere antibody; 7) SS-A or SS-B; 8) Jo-1 antibody | Positive finding of at least one of: 1) ANA; 2) RF; 3) anti-Scl70 antibody; 4) SS-A or SS-B; 5) Jo-1 antibody; 6) ESR (>2 times normal), CRP |
CTD: connective tissue disease; ANA: antinuclear antibody; RF: rheumatoid factor; ENA: extractable nuclear antigen; RNP: ribonucleoprotein; SS-A: anti-Ro; SS-B: anti-La; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein. #: a diagnosis of UCTD requires having one or more of the symptoms outlined in A, and one or more of the laboratory findings listed in B; ¶: criteria proposed by Kinder et al. [5]. Reproduced from [6] with permission.