Table 1. Key symptoms to detect underlying connective tissue disease
OrganMain manifestations to be evaluated#
Peripheral circulationRaynaud’s phenomenon
Digital ulcerations or scars
Violaceous erythematous rash over the interphalangeal joints, knuckles, elbows and knees (Gottron's sign)
Lilaceous rash of the eyelids
Rash of the neck and upper chest and shoulders (heliotrope rash, e.g. photosensitivity)
Mechanics’ hand
JointsJoint pain or swelling (arthritis, arthralgia)
Morning stiffness
MuscleMuscle pain and muscle weakness
Mouth and eyesDry mouth and dry eyes (sicca syndrome)
  • #: this list is not exhaustive.