| Organ | Main manifestations to be evaluated# |
| Peripheral circulation | Raynaud’s phenomenon |
| Skin | Sclerodactily |
| Digital ulcerations or scars | |
| Telangiectasia | |
| Violaceous erythematous rash over the interphalangeal joints, knuckles, elbows and knees (Gottron's sign) | |
| Lilaceous rash of the eyelids | |
| Rash of the neck and upper chest and shoulders (heliotrope rash, e.g. photosensitivity) | |
| Mechanics’ hand | |
| Joints | Joint pain or swelling (arthritis, arthralgia) Morning stiffness |
| Muscle | Muscle pain and muscle weakness |
| Mouth and eyes | Dry mouth and dry eyes (sicca syndrome) |
#: this list is not exhaustive.