Table 6. Meta-analysis of smoking cessation trials in chronic obstructive pulmonary disease patients

Study	Subjects n	Prolonged abstinence rate
Lung Health Study [36]	5887	12 months: 34% versus 9% (NRT)
Hilberink [37]	392	6 months: 16% versus 9% (NRT)
TØnnesen [20]	370	12 months: 14% versus 5% (NRT)
Tashkin [21]	404	6 months: 16% versus 9% (BUP)
Wagena [38]	255	6 months: 30% versus 19% (BUP)
Pederson [39]	64	6 months 27% versus 16%
Crowley [40]	49	6 months: 14% versus 14%
Brandt [41]	56	12 months: 32% versus 16%
Tashkin [22]	499	12 months: 19% versus 6% (VAR)

Data are presented as abstinence rates for intervention versus control groups. NRT: nicotine replacement therapy; BUP: bupropion SR; VAR: varenicline. Reproduced from [35] with permission from the publisher.