Table 2. Lung function impairment at diagnosis and outcome of occupational asthma

First author [ref.]	Main conclusion	SIGN grade	Study type	Exposure/ occupation	Subjects n
Merget [10]	No relationship (NSBHR)	2-	Cohort study	Platinum salts	275
Tarlo [11]	+ (NSBHR, FEV₁, FVC)	3	Descriptive study of register	Isocyanates	235
Cote [12]	+ (SIC), no relationship (FEV₁, FVC, NSBHR)	2+	Longitudinal	Plicatic acid (Western red cedar)	48
Sorgdrager [13]	+ (FEV₁)	2-	Longitudinal	Fluorides	122
Pisati [14]	No relationship (FEV₁, VC, NSBHR)	2-	Longitudinal	TDI	25
Perfetti [15]	+ (NSBHR, FEV₁)	2-	Longitudinal	Various HMW and LMW agents	99
Park [16]	+ (NSBHR)	2-	Longitudinal	TDI	35
Chang-Yeung [17]	+ (NSBHR, FEV₁,FVC)	2-	Longitudinal	Western red cedar	125
Maghni [8]	+ (NSBHR)	2+	Longitudinal	Various HMW and LMW agents	133
Lozewicz [18]	+ (NSBHR, FEV₁)	2+	Longitudinal	Isocyanates (TDI, MDI)	56
Hudson [19]	+ (FEV₁)	2-	Longitudinal	Crab; various HMW and LMW agents	63
Malo [20]	+ (NSBHR, FEV₁)	2+	Longitudinal	Various HMW and LMW agents	80
Park [21]	+ (NSBHR)	2-	Longitudinal	TDI	41
Mapp [22]	+ (SIC), no relationship (FEV₁, NSBHR)	2-	Longitudinal	TDI	35
Labreque [23]	+ (NSBHR, FEV₁)	2-	Longitudinal	Isocyanates	79
Padoan [9]	+ (NSBHR, FEV₁)	2++	Longitudinal	TDI	87
Soyseth [24]	- (Higher NSBHR at baseline favours good prognosis), no relationship (FEV₁)	2+	Longitudinal	Fluorides	38
Moscato [25]	+ (FEV₁)	2+	Longitudinal	Various	29

SIGN: Scottish Intercollegiate Guidelines Network; NSBHR: nonspecific bronchial hyperresponsiveness; FEV₁: forced expiratory volume in 1 s; FVC: forced vital capacity; SIC: specific inhalation challenge; VC: vital capacity; TDI: toluene diisocyanate; HMW: high molecular weight; LMW: low molecular weight; MDI: methylene diphenyl diisocyanate. +: relationship between worse lung function at baseline (FEV₁, FVC, VC, NSBHR and SIC) and worse asthma status at follow-up; - : relationship between worse lung function at baseline (FEV₁, FVC, VC, NSBHR and SIC) and better asthma status at follow-up.