Pifenidone# 2403 mg·day−1 | Placebo¶ | Hazard ratio (95% CI)+ | p-value§ | |
Overall | ||||
All-cause mortality | 27 (8) | 34 (10) | 0.77 (0.47–1.28) | 0.315 |
IPF-related mortalityƒ | 18 (5) | 28 (8) | 0.62 (0.35–1.13) | 0.117 |
On-treatment## | ||||
All-cause mortality | 19 (6) | 29 (8) | 0.65 (0.36–1.16) | 0.141 |
IPF-related mortalityƒ | 12 (3) | 25 (7) | 0.48 (0.24–0.95) | 0.030 |
Data are presented as n (%), unless otherwise stated. IPF: idiopathic pulmonary fibrosis; CAPACITY: Clinical Studies Assessing Pirfenidone in IPF: Research of Efficacy and Safety Outcomes. #: n=345; ¶: n=347; +: based on the Cox-proportional hazard model; §: log-rank test (pirfenidone 2403 mg·day−1 versus placebo); ƒ: assessed by the investigator, who remained blinded to treatment assignment; ##: defined as the time from randomisation until 28 days after the last dose of study drug. Reproduced from [22] with permission from the publisher.