| Diuretics |
| Slowly increased |
| Oral: bumetamide up to 10 mg (b.i.d. or t.i.d.) |
| i.v. drip if necessary (1 mg per h) |
| Association with spironolactone 50–100 mg and chlorthalidone 50 mg |
| Switch from bumetamide to furosemide up to 600 mg |
| Sodium and fluid restriction |
| Sometimes haemofiltration |
| Intermittent paracentesis for therapy-resistant ascites and pleural effusion |
| Inotropes |
| 7-day course |
| Dobutamine 4–6 μg·kg−1·min−1 (peripheral administration is acceptable) |
| Low blood pressure: dopamine 4–6 μg·kg−1·min−1 |
| Heart rate >110 beats per min + digoxine 0.5 mg i.v. |
| Vasodilators |
| Seldom needed |
| Inhaled NO 10–20 ppm |
| Inhaled iloprost 150 μg per day (every 2–3 h or even continuously) |