Table. 1—

Evolution of functional and haemodynamic characteristics

August 2003December 2003September 2004February 2005May 2005
NYHA functional classIIIIIIIIIIII
6MWT
    Distance m412475450445485
    Nadir Sp,O2 %8795958287
    Borg index2.51010.5
Mean Ppa (s/d) mmHg50 (80/35)38 (60/25)52 (85/35)57 (91/38)41 (69/19)
Pra mmHg5763
Ppcw mmHg44795
Cardiac index L·min−1·m−22.43.13.72.92.8
TPRi U·m−22112.314.119.714.7
PVRi U·m−219.31112.216.612.9
Sv,O2 %68667167
Acute vasodilatation testNegative
Specific PAH therapyNoneBosentan for the past 4 monthsBosentan for the past 12 monthsBosentan for the past 18 monthsBosentan and iloprost for the past 3 months
  • NYHA: New York Heart Association; 6MWT: 6-min walk test; Sp,O2: arterial oxygen saturation measured by pulse oximetry; Ppa: pulmonary artery pressure; s: systolic; d: diastolic; Pra: right atrial pressure; Ppcw: pulmonary capillary wedge pressure; TPRi: total pulmonary resistance index; PVRi: pulmonary vascular resistance index; Sv,O2: mixed venous oxygen saturation; PAH: pulmonary arterial hypertension.