Most common adverse events experienced by chronic obstructive pulmonary disease patients treated with cilomilast or placebo in four clinical trials with this phosphodiesterase 4 inhibitor.
| Placebo | Cilomilast | |
| Patients n | 1091 | 1792 |
| Adverse event | 76.9 | 78.3 |
| COPD | 36.2 | 30.4 |
| Nausea | 5.0 | 15.7 |
| Diarrhoea | 7.9 | 14.4 |
| Abdominal pain | 7.1 | 11.7 |
| Upper respiratory tract infection | 10.3 | 8.8 |
| Headache | 7.0 | 8.2 |
| Dyspepsia | 2.5 | 6.8 |
| Vomiting | 1.6 | 6.1 |
| Injury | 5.0 | 5.4 |
| Coughing | 5.3 | 3.5 |
Data presented as %, unless otherwise stated. From [20].