PT  - JOURNAL ARTICLE
AU  - Herth, Jonas
AU  - Sievi, Noriane Adriana
AU  - Schmidt, Felix
AU  - Kohler, Malcolm
TI  - Effects of continuous positive airway pressure therapy on glucose metabolism in patients with obstructive sleep apnoea and type 2 diabetes: a systematic review and meta-analysis
AID  - 10.1183/16000617.0083-2023
DP  - 2023 Sep 30
TA  - European Respiratory Review
PG  - 230083
VI  - 32
IP  - 169
4099  - http://err.ersjournals.com/content/32/169/230083.short
4100  - http://err.ersjournals.com/content/32/169/230083.full
SO  - EUROPEAN RESPIRATORY REVIEW2023 Sep 30; 32
AB  - Obstructive sleep apnoea is a highly prevalent chronic disorder and has been shown to be associated with disturbed glucose metabolism and type 2 diabetes. However, the evidence from individual clinical trials on the effect of continuous positive airway pressure (CPAP) treatment on glycaemic control in patients with co-existing obstructive sleep apnoea and type 2 diabetes remains controversial. A systematic review of randomised controlled trials assessing the effect of CPAP on glycaemic control in patients with obstructive sleep apnoea and type 2 diabetes was conducted using the databases MEDLINE, Embase, Cochrane and Scopus up to December 2022. Meta-analysis using a random-effect model was performed for outcomes that were reported in at least two randomised controlled trials. From 3031 records screened, 11 RCTs with a total of 964 patients were included for analysis. CPAP treatment led to a significant reduction in haemoglobin A1c (HbA1c) (mean difference −0.24%, 95% CI −0.43– −0.06%, p=0.001) compared to inactive control groups. Meta-regression showed a significant association between reduction in HbA1c and hours of nightly CPAP usage. CPAP therapy seems to significantly improve HbA1c and thus long-term glycaemic control in patients with type 2 diabetes and obstructive sleep apnoea. The amount of improvement is dependent on the hours of usage of CPAP and thus optimal adherence to CPAP should be a primary goal in these patients.CPAP therapy seems to significantly improve HbA1c in patients with type 2 diabetes and OSA. The amount of improvement is associated with the hours of usage of CPAP; optimal adherence to CPAP should be a primary goal in these patients. https://bit.ly/3CZL9ic