RT Journal Article
SR Electronic
T1 Regenerative and translational medicine in COPD: hype and hope
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 220223
DO 10.1183/16000617.0223-2022
VO 32
IS 169
A1 Lucas Pires Guarnier
A1 Lincoln Gozzi Moro
A1 Francislaine Aparecida dos Reis Lívero
A1 Carolina Arruda de Faria
A1 Mauricio Fogaça Azevedo
A1 Beatriz Pizoni Roma
A1 Edilson Rodrigues Albuquerque
A1 Maria José Malagutti-Ferreira
A1 Alessandra Gomes Duarte Rodrigues
A1 Adelson Alves da Silva
A1 Eliseo Joji Sekiya
A1 João Tadeu Ribeiro-Paes
YR 2023
UL http://err.ersjournals.com/content/32/169/220223.abstract
AB COPD is a common, preventable and usually progressive disease associated with an enhanced chronic inflammatory response in the airways and lung, generally caused by exposure to noxious particles and gases. It is a treatable disease characterised by persistent respiratory symptoms and airflow limitation due to abnormalities in the airways and/or alveoli. COPD is currently the third leading cause of death worldwide, representing a serious public health problem and a high social and economic burden. Despite significant advances, effective clinical treatments have not yet been achieved. In this scenario, cell-based therapies have emerged as potentially promising therapeutic approaches. However, there are only a few published studies of cell-based therapies in human patients with COPD and a small number of ongoing clinical trials registered on clinicaltrials.gov. Despite the advances and interesting results, numerous doubts and questions remain about efficacy, mechanisms of action, culture conditions, doses, timing, route of administration and conditions related to homing and engraftment of the infused cells. This article presents the state of the art of cell-based therapy in COPD. Clinical trials that have already been completed and with published results are discussed in detail. We also discuss the questions that remain unanswered about cell-based regenerative and translational medicine for COPD.This review describes the current state of the art of cell-based, regenerative and translational medicine in COPD, presenting the clinical trials already completed and with published results. https://bit.ly/3P08Bmq