PT  - JOURNAL ARTICLE
AU  - D'Cruz, Rebecca F.
AU  - Kaltsakas, Georgios
AU  - Suh, Eui-Sik
AU  - Hart, Nicholas
TI  - Quality of life in patients with chronic respiratory failure on home mechanical ventilation
AID  - 10.1183/16000617.0237-2022
DP  - 2023 Jun 30
TA  - European Respiratory Review
PG  - 220237
VI  - 32
IP  - 168
4099  - http://err.ersjournals.com/content/32/168/220237.short
4100  - http://err.ersjournals.com/content/32/168/220237.full
SO  - EUROPEAN RESPIRATORY REVIEW2023 Jun 30; 32
AB  - Home mechanical ventilation (HMV) is a treatment for chronic respiratory failure that has shown clinical and cost effectiveness in patients with underlying COPD, obesity-related respiratory failure and neuromuscular disease (NMD). By treating chronic respiratory failure with adequate adherence to HMV, improvement in patient-reported outcomes including health-related quality of life (HRQoL) have been evaluated using general and disease-specific quantitative, semi-qualitative and qualitative methods. However, the treatment response in terms of trajectory of change in HRQoL is not uniform across the restrictive and obstructive disease groups. In this review, the effect of HMV on HRQoL across the domains of symptom perception, physical wellbeing, mental wellbeing, anxiety, depression, self-efficacy and sleep quality in stable and post-acute COPD, rapidly progressive NMD (such as amyotrophic lateral sclerosis), inherited NMD (including Duchenne muscular dystrophy) and obesity-related respiratory failure will be discussed.Home ventilation can improve clinical outcomes for patients with COPD, obesity-related respiratory failure and neuromuscular disease. A range of modifiable and nonmodifiable factors influence its impact upon patients’ health-related quality of life. https://bit.ly/3Xsak4I