PT  - JOURNAL ARTICLE
AU  - Daniel B. Oakes
AU  - Megan J. Baker
AU  - Charlie McLeod
AU  - Barbara Nattabi
AU  - Christopher C. Blyth
TI  - Patient-reported outcome measures for paediatric acute lower respiratory infection studies
AID  - 10.1183/16000617.0229-2022
DP  - 2023 Mar 31
TA  - European Respiratory Review
PG  - 220229
VI  - 32
IP  - 167
4099  - http://err.ersjournals.com/content/32/167/220229.short
4100  - http://err.ersjournals.com/content/32/167/220229.full
SO  - EUROPEAN RESPIRATORY REVIEW2023 Mar 31; 32
AB  - Background Patient-reported outcome measures (PROMs) are recommended for capturing meaningful outcomes in clinical trials. The use of PROMs for children with acute lower respiratory infections (ALRIs) has not been systematically reported. We aimed to identify and characterise patient-reported outcomes and PROMs used in paediatric ALRI studies and summarise their measurement properties.Methods Medline, Embase and Cochrane were searched (until April 2022). Studies that reported on patient-reported outcome (or measure) use or development and included subjects aged <18 years with ALRIs were included. Study, population and patient-reported outcome (or measure) characteristics were extracted.Results Of 2793 articles identified, 18 met inclusion criteria, including 12 PROMs. Two disease-specific PROMs were used in settings in which they had been validated. The Canadian Acute Respiratory Illness and Flu Scale was the most frequently used disease-specific PROM (five studies). The EuroQol-Five Dimensions-Youth system was the most frequently used generic PROM (two studies). There was considerable heterogeneity in validation methods. The outcome measures identified in this review lack validation for young children and none involve sufficient content validity for use with First Nations children.Conclusions There is an urgent need for PROM development that considers the populations in which the burden of ALRI predominates.This review found a lack of patient-reported outcome measures (PROMs) for paediatric acute lower respiratory infection (ALRI). PROM development that incorporates modern validation methods and considers those experiencing the greatest ALRI burden is needed. https://bit.ly/3iXVwfY