PT  - JOURNAL ARTICLE
AU  - Nadia Nathan
AU  - Matthias Griese
AU  - Katarzyna Michel
AU  - Julia Carlens
AU  - Carlee Gilbert
AU  - Nagehan Emiralioglu
AU  - Alba Torrent-Vernetta
AU  - Honorata Marczak
AU  - Brigitte Willemse
AU  - Céline Delestrain
AU  - Ralph Epaud
ED  - ,
TI  - Diagnostic workup of childhood interstitial lung disease
AID  - 10.1183/16000617.0188-2022
DP  - 2023 Mar 31
TA  - European Respiratory Review
PG  - 220188
VI  - 32
IP  - 167
4099  - http://err.ersjournals.com/content/32/167/220188.short
4100  - http://err.ersjournals.com/content/32/167/220188.full
SO  - EUROPEAN RESPIRATORY REVIEW2023 Mar 31; 32
AB  - Childhood interstitial lung diseases (chILDs) are rare and heterogeneous diseases with significant morbidity and mortality. An accurate and quick aetiological diagnosis may contribute to better management and personalised treatment. On behalf of the European Respiratory Society Clinical Research Collaboration for chILD (ERS CRC chILD-EU), this review summarises the roles of the general paediatrician, paediatric pulmonologists and expert centres in the complex diagnostic workup. Each patient's aetiological chILD diagnosis must be reached without prolonged delays in a stepwise approach from medical history, signs, symptoms, clinical tests and imaging, to advanced genetic analysis and specialised procedures including bronchoalveolar lavage and biopsy, if necessary. Finally, as medical progress is fast, the need to revisit a diagnosis of “undefined chILD” is stressed.Childhood interstitial lung diseases are rare and severe diseases. A stepwise approach to an aetiological diagnosis includes specific investigations performed in expert centres. The term “undefined chILD” must be regularly reassessed. https://bit.ly/3YIWKvn