RT Journal Article
SR Electronic
T1 Immune mechanisms in fibrotic pulmonary sarcoidosis
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 220178
DO 10.1183/16000617.0178-2022
VO 31
IS 166
A1 Weeratunga, Praveen
A1 Moller, David R.
A1 Ho, Ling-Pei
YR 2022
UL http://err.ersjournals.com/content/31/166/220178.abstract
AB Sarcoidosis is an immune-mediated disorder. Its immunopathology has been steadily mapped out over the past few decades. Despite this, the underpinning mechanisms for progressive fibrotic sarcoidosis is an almost uncharted area. Consequently, there has been little change in the clinical management of fibrotic sarcoidosis over the decades and an unfocused search for new therapeutics. In this review, we provide a comprehensive examination of the relevant immune findings in fibrotic and/or progressive pulmonary sarcoidosis and propose a unifying mechanism for the pathobiology of fibrosis in sarcoidosis.This review provides a comprehensive examination of relevant immune findings in fibrotic sarcoidosis and draws on these to propose a unifying mechanism for the pathobiology of disease. https://bit.ly/3TR4SaB