TY - JOUR T1 - Immune mechanisms in fibrotic pulmonary sarcoidosis JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW DO - 10.1183/16000617.0178-2022 VL - 31 IS - 166 SP - 220178 AU - Praveen Weeratunga AU - David R. Moller AU - Ling-Pei Ho Y1 - 2022/12/31 UR - http://err.ersjournals.com/content/31/166/220178.abstract N2 - Sarcoidosis is an immune-mediated disorder. Its immunopathology has been steadily mapped out over the past few decades. Despite this, the underpinning mechanisms for progressive fibrotic sarcoidosis is an almost uncharted area. Consequently, there has been little change in the clinical management of fibrotic sarcoidosis over the decades and an unfocused search for new therapeutics. In this review, we provide a comprehensive examination of the relevant immune findings in fibrotic and/or progressive pulmonary sarcoidosis and propose a unifying mechanism for the pathobiology of fibrosis in sarcoidosis.This review provides a comprehensive examination of relevant immune findings in fibrotic sarcoidosis and draws on these to propose a unifying mechanism for the pathobiology of disease. https://bit.ly/3TR4SaB ER -