RT Journal Article
SR Electronic
T1 The role of gene–ambient air pollution interactions in paediatric asthma
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 220094
DO 10.1183/16000617.0094-2022
VO 31
IS 166
A1 Jelte Kelchtermans
A1 Hakon Hakonarson
YR 2022
UL http://err.ersjournals.com/content/31/166/220094.abstract
AB Globally, asthma prevention and treatment remain a challenge. Ambient air pollution (AAP) is an environmental risk factor of special interest in asthma research. AAP is poorly defined and has been subdivided either by the origin of the air pollution or by the specific bioactive compounds. The link between AAP exposure and asthma exacerbations is well established and has been extensively reviewed. In this narrative review, we discuss the specific genetic variants that have been associated with increased AAP sensitivity and impact in paediatric asthma. We highlight the relative importance of variants associated with genes with a role in oxidant defences and the nuclear factor-κB pathway supporting a potential central role for these pathways in AAP sensitivity.Genetic variants impact the sensitivity to ambient air pollution (AAP) in paediatric patients with asthma. Variants associated with oxidative stress or nuclear factor-κB pathways are linked to AAP sensitivity. https://bit.ly/3wYmLun