TY - JOUR T1 - The role of gene–ambient air pollution interactions in paediatric asthma JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW DO - 10.1183/16000617.0094-2022 VL - 31 IS - 166 SP - 220094 AU - Jelte Kelchtermans AU - Hakon Hakonarson Y1 - 2022/12/31 UR - http://err.ersjournals.com/content/31/166/220094.abstract N2 - Globally, asthma prevention and treatment remain a challenge. Ambient air pollution (AAP) is an environmental risk factor of special interest in asthma research. AAP is poorly defined and has been subdivided either by the origin of the air pollution or by the specific bioactive compounds. The link between AAP exposure and asthma exacerbations is well established and has been extensively reviewed. In this narrative review, we discuss the specific genetic variants that have been associated with increased AAP sensitivity and impact in paediatric asthma. We highlight the relative importance of variants associated with genes with a role in oxidant defences and the nuclear factor-κB pathway supporting a potential central role for these pathways in AAP sensitivity.Genetic variants impact the sensitivity to ambient air pollution (AAP) in paediatric patients with asthma. Variants associated with oxidative stress or nuclear factor-κB pathways are linked to AAP sensitivity. https://bit.ly/3wYmLun ER -