RT Journal Article
SR Electronic
T1 Prognostic factors for mortality, intensive care unit and hospital admission due to SARS-CoV-2: a systematic review and meta-analysis of cohort studies in Europe
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 220098
DO 10.1183/16000617.0098-2022
VO 31
IS 166
A1 Constantine I. Vardavas
A1 Alexander G. Mathioudakis
A1 Katerina Nikitara
A1 Kimon Stamatelopoulos
A1 Georgios Georgiopoulos
A1 Revati Phalkey
A1 Jo Leonardi-Bee
A1 Esteve Fernandez
A1 Dolors Carnicer-Pont
A1 Jørgen Vestbo
A1 Jan C. Semenza
A1 Charlotte Deogan
A1 Jonathan E. Suk
A1 Piotr Kramarz
A1 Favelle Lamb
A1 Pasi Penttinen
YR 2022
UL http://err.ersjournals.com/content/31/166/220098.abstract
AB Background As mortality from coronavirus disease 2019 (COVID-19) is strongly age-dependent, we aimed to identify population subgroups at an elevated risk for adverse outcomes from COVID-19 using age-/gender-adjusted data from European cohort studies with the aim to identify populations that could potentially benefit from booster vaccinations.Methods We performed a systematic literature review and meta-analysis to investigate the role of underlying medical conditions as prognostic factors for adverse outcomes due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including death, hospitalisation, intensive care unit (ICU) admission and mechanical ventilation within three separate settings (community, hospital and ICU). Cohort studies that reported at least age and gender-adjusted data from Europe were identified through a search of peer-reviewed articles published until 11 June 2021 in Ovid Medline and Embase. Results are presented as odds ratios with 95% confidence intervals and absolute risk differences in deaths per 1000 COVID-19 patients.Findings We included 88 cohort studies with age-/gender-adjusted data from 6 653 207 SARS-CoV-2 patients from Europe. Hospital-based mortality was associated with high and moderate certainty evidence for solid organ tumours, diabetes mellitus, renal disease, arrhythmia, ischemic heart disease, liver disease and obesity, while a higher risk, albeit with low certainty, was noted for chronic obstructive pulmonary disease and heart failure. Community-based mortality was associated with a history of heart failure, stroke, diabetes and end-stage renal disease. Evidence of high/moderate certainty revealed a strong association between hospitalisation for COVID-19 and solid organ transplant recipients, sleep apnoea, diabetes, stroke and liver disease.Interpretation The results confirmed the strong association between specific prognostic factors and mortality and hospital admission. Prioritisation of booster vaccinations and the implementation of nonpharmaceutical protective measures for these populations may contribute to a reduction in COVID-19 mortality, ICU and hospital admissions.There is a strong association between specific prognostic factors and mortality and hospital admission due to SARS-CoV-2, including, but not limited to, diabetes, cardiovascular diseases and respiratory diseases. https://bit.ly/3Qo4zCc