PT - JOURNAL ARTICLE AU - Cilloniz, Catia AU - Luna, Carlos M. AU - Hurtado, Juan Carlos AU - Marcos, María Ángeles AU - Torres, Antoni TI - Respiratory viruses: their importance and lessons learned from COVID-19 AID - 10.1183/16000617.0051-2022 DP - 2022 Dec 31 TA - European Respiratory Review PG - 220051 VI - 31 IP - 166 4099 - https://publications.ersnet.org//content/31/166/220051.short 4100 - https://publications.ersnet.org//content/31/166/220051.full SO - EUROPEAN RESPIRATORY REVIEW2022 Dec 31; 31 AB - Respiratory virus infection can cause severe illnesses capable of inducing acute respiratory failure that can progress rapidly to acute respiratory distress syndrome (ARDS). ARDS is related to poor outcomes, especially in individuals with a higher risk of infection, such as the elderly and those with comorbidities, i.e. obesity, asthma, diabetes mellitus and chronic respiratory or cardiovascular disease. Despite this, effective antiviral treatments available for severe viral lung infections are scarce. The coronavirus disease 2019 (COVID-19) pandemic demonstrated that there is also a need to understand the role of airborne transmission of respiratory viruses. Robust evidence supporting this exists, but better comprehension could help implement adequate measures to mitigate respiratory viral infections. In severe viral lung infections, early diagnosis, risk stratification and prognosis are essential in managing patients. Biomarkers can provide reliable, timely and accessible information possibly helpful for clinicians in managing severe lung viral infections. Although respiratory viruses highly impact global health, more research is needed to improve care and prognosis of severe lung viral infections. In this review, we discuss the epidemiology, diagnosis, clinical characteristics, management and prognosis of patients with severe infections due to respiratory viruses.Respiratory viruses can cause severe disease with poor outcomes, especially in individuals with a higher risk of infection. Early identification, epidemiological tracing, and preventative and therapeutic measures are crucial to limiting their spread. https://bit.ly/3mpuFat