RT Journal Article SR Electronic T1 Physical activity and its correlates in people with cystic fibrosis: a systematic review JF European Respiratory Review JO EUROPEAN RESPIRATORY REVIEW FD European Respiratory Society SP 220010 DO 10.1183/16000617.0010-2022 VO 31 IS 165 A1 Kinaupenne, Manon A1 De Craemer, Marieke A1 Schaballie, Heidi A1 Vandekerckhove, Kristof A1 Van Biervliet, Stephanie A1 Demeyer, Heleen YR 2022 UL http://err.ersjournals.com/content/31/165/220010.abstract AB Cystic fibrosis (CF) is a life-shortening genetic disease, affecting multiple life domains including physical activity (PA). Although higher PA levels are associated with multiple health benefits, little insight exists on the PA level of people with CF (PwCF) compared to healthy peers. Evidence on the influencing factors (i.e. correlates) of PA in this clinical population is scarce, but essential to fully understand their PA behaviour. Therefore, the present review aims to provide an overview of the PA level of PwCF compared to healthy peers, and the correlates of PA in PwCF. A systematic search of three databases resulted in 46 included studies. Analysis of 16 studies showed that the CF population is equally active compared to healthy peers, but there is a trend towards less high-intensity PA in youths with CF. Furthermore, PA is positively associated with quality of life, lung function, (maximal) exercise capacity, bone mineral density and quadriceps force. Also, PA was lower on weekdays compared to weekend days and lower when experiencing pulmonary exacerbations. More high-quality research is required in PwCF, particularly longitudinal studies that further explore the correlates of PA, with PA investigated as a primary outcome and measured objectively.PwCF are as active as their healthy peers but a trend for less high-intensity PA is seen in youths with CF. This systematic review stresses the need for high-quality longitudinal studies to further unravel the PA levels of PwCF and its influencing factors. https://bit.ly/3npYkRn