RT Journal Article SR Electronic T1 The prevalence and related factors of fatigue in patients with COPD: a systematic review JF European Respiratory Review JO EUROPEAN RESPIRATORY REVIEW FD European Respiratory Society SP 200298 DO 10.1183/16000617.0298-2020 VO 30 IS 160 A1 Zjala Ebadi A1 Yvonne M.J. Goërtz A1 Maarten Van Herck A1 Daisy J.A. Janssen A1 Martijn A. Spruit A1 Chris Burtin A1 Melissa S.Y. Thong A1 Jean Muris A1 Jacqueline Otker A1 Milou Looijmans A1 Christel Vlasblom A1 Joëlle Bastiaansen A1 Judith Prins A1 Emiel F.M Wouters A1 Jan H. Vercoulen A1 Jeannette B. Peters YR 2021 UL http://err.ersjournals.com/content/30/160/200298.abstract AB Background Fatigue is a distressing symptom in patients with COPD. Little is known about the factors that contribute to fatigue in COPD. This review summarises existing knowledge on the prevalence of fatigue, factors related to fatigue and the instruments most commonly used to assess fatigue in COPD.Methods Pubmed, PsycINFO, EMBASE, Cochrane and CINAHL databases were searched for studies from inception up to 7 January 2020 using the medical subject headings “COPD” and “Fatigue”. Studies were reviewed in accordance with PRISMA guidelines.Results 196 studies were evaluated. The prevalence of fatigue ranged from 17–95%. Age (r=−0.23 to r=0.27), sex (r=0.11), marital status (r=−0.096), dyspnoea (r=0.13 to r=0.78), forced expiatory volume in 1 s % predicted (r=−0.55 to r=−0.076), number of exacerbations (r=0.27 to r=0.38), number of comorbidities (r=0.10), number of medications (r=0.35), anxiety (r=0.36 to r=0.61), depression (r=0.41 to r=0.66), muscle strength (r=−0.78 to r=−0.45), functional capacity (r=−0.77 to r=−0.14) and quality of life (r=0.48 to r=0.77) showed significant associations with fatigue.Conclusions Fatigue is a prevalent symptom in patients with COPD. Multiple physical and psychological factors seem to be associated with fatigue. Future studies are needed to evaluate these underlying factors in integral analyses in samples of patients with COPD.Fatigue is an important symptom in COPD. In the 196 evaluated studies, prevalence of fatigue ranged from 17–95%. Physical, psychological and demographic factors are associated with fatigue in COPD. Further studies are needed to evaluate these underlying factors. https://bit.ly/3q2BRcE