TY - JOUR T1 - The prevalence and related factors of fatigue in patients with COPD: a systematic review JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW DO - 10.1183/16000617.0298-2020 VL - 30 IS - 160 SP - 200298 AU - Zjala Ebadi AU - Yvonne M.J. Goërtz AU - Maarten Van Herck AU - Daisy J.A. Janssen AU - Martijn A. Spruit AU - Chris Burtin AU - Melissa S.Y. Thong AU - Jean Muris AU - Jacqueline Otker AU - Milou Looijmans AU - Christel Vlasblom AU - Joëlle Bastiaansen AU - Judith Prins AU - Emiel F.M Wouters AU - Jan H. Vercoulen AU - Jeannette B. Peters Y1 - 2021/06/30 UR - http://err.ersjournals.com/content/30/160/200298.abstract N2 - Background Fatigue is a distressing symptom in patients with COPD. Little is known about the factors that contribute to fatigue in COPD. This review summarises existing knowledge on the prevalence of fatigue, factors related to fatigue and the instruments most commonly used to assess fatigue in COPD.Methods Pubmed, PsycINFO, EMBASE, Cochrane and CINAHL databases were searched for studies from inception up to 7 January 2020 using the medical subject headings “COPD” and “Fatigue”. Studies were reviewed in accordance with PRISMA guidelines.Results 196 studies were evaluated. The prevalence of fatigue ranged from 17–95%. Age (r=−0.23 to r=0.27), sex (r=0.11), marital status (r=−0.096), dyspnoea (r=0.13 to r=0.78), forced expiatory volume in 1 s % predicted (r=−0.55 to r=−0.076), number of exacerbations (r=0.27 to r=0.38), number of comorbidities (r=0.10), number of medications (r=0.35), anxiety (r=0.36 to r=0.61), depression (r=0.41 to r=0.66), muscle strength (r=−0.78 to r=−0.45), functional capacity (r=−0.77 to r=−0.14) and quality of life (r=0.48 to r=0.77) showed significant associations with fatigue.Conclusions Fatigue is a prevalent symptom in patients with COPD. Multiple physical and psychological factors seem to be associated with fatigue. Future studies are needed to evaluate these underlying factors in integral analyses in samples of patients with COPD.Fatigue is an important symptom in COPD. In the 196 evaluated studies, prevalence of fatigue ranged from 17–95%. Physical, psychological and demographic factors are associated with fatigue in COPD. Further studies are needed to evaluate these underlying factors. https://bit.ly/3q2BRcE ER -