PT - JOURNAL ARTICLE AU - Fleitas Sosa, Derlis AU - Lehr, Andrew L. AU - Zhao, Huaqing AU - Roth, Stephanie AU - Lakhther, Vlad AU - Bashir, Riyaz AU - Cohen, Gary AU - Panaro, Joseph AU - Maldonado, Thomas S. AU - Horowitz, James AU - Amoroso, Nancy E. AU - Criner, Gerard J. AU - Brosnahan, Shari B. AU - Rali, Parth TI - Impact of pulmonary embolism response teams on acute pulmonary embolism: a systematic review and meta-analysis AID - 10.1183/16000617.0023-2022 DP - 2022 Sep 30 TA - European Respiratory Review PG - 220023 VI - 31 IP - 165 4099 - https://publications.ersnet.org//content/31/165/220023.short 4100 - https://publications.ersnet.org//content/31/165/220023.full SO - EUROPEAN RESPIRATORY REVIEW2022 Sep 30; 31 AB - Background The impact of pulmonary embolism response teams (PERTs) on treatment choice and outcomes of patients with acute pulmonary embolism (PE) is still uncertain.Objective To determine the effect of PERTs in the management and outcomes of patients with PE.Methods PubMed, Embase, Web of Science, CINAHL, WorldWideScience and MedRxiv were searched for original articles reporting PERT patient outcomes from 2009. Data were analysed using a random effects model.Results 16 studies comprising 3827 PERT patients and 3967 controls met inclusion criteria. The PERT group had more patients with intermediate and high-risk PE (66.2%) compared to the control group (48.5%). Meta-analysis demonstrated an increased risk of catheter-directed interventions, systemic thrombolysis and surgical embolectomy (odds ratio (OR) 2.10, 95% confidence interval (CI) 1.74–2.53; p<0.01), similar bleeding complications (OR 1.10, 95% CI 0.88–1.37) and decreased utilisation of inferior vena cava (IVC) filters (OR 0.71, 95% CI 0.58–0.88; p<0.01) in the PERT group. Furthermore, there was a nonsignificant trend towards decreased mortality (OR 0.87, 95% CI 0.71–1.07; p=0.19) with PERTs.Conclusions The PERT group showed an increased use of advanced therapies and a decreased utilisation of IVC filters. This was not associated with increased bleeding. Despite comprising more severe PE patients, there was a trend towards lower mortality in the PERT group.Pulmonary embolism response teams increase use of advanced therapies for pulmonary embolism without increasing bleeding complications https://bit.ly/39NJZuw