PT - JOURNAL ARTICLE AU - Deprato, Andy AU - Ferrara, Giovanni AU - Bhutani, Mohit AU - Melenka, Lyle AU - Murgia, Nicola AU - Usmani, Omar S. AU - Lacy, Paige AU - Moitra, Subhabrata TI - Reference equations for oscillometry and their differences among populations: a systematic scoping review AID - 10.1183/16000617.0021-2022 DP - 2022 Sep 30 TA - European Respiratory Review PG - 220021 VI - 31 IP - 165 4099 - http://err.ersjournals.com/content/31/165/220021.short 4100 - http://err.ersjournals.com/content/31/165/220021.full SO - EUROPEAN RESPIRATORY REVIEW2022 Sep 30; 31 AB - Respiratory oscillometry is gaining global attention over traditional pulmonary function tests for its sensitivity in detecting small airway obstructions. However, its use in clinical settings as a diagnostic tool is limited because oscillometry lacks globally accepted reference values. In this scoping review, we systematically assessed the differences between selected oscillometric reference equations with the hypothesis that significant heterogeneity existed between them. We searched bibliographic databases, registries and references for studies that developed equations for healthy adult populations according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A widely used Caucasian model was used as the standard reference and compared against other models using Bland–Altman and Lin's concordance correlational analyses. We screened 1202 titles and abstracts, and after a full-text review of 67 studies, we included 10 in our analyses. Of these, three models had a low-to-moderate agreement with the reference model, particularly those developed from non-Caucasian populations. Although the other six models had a moderate-to-high agreement with the standard model, there were still significant sex-specific variations. This is the first systematic analysis of the heterogeneity between oscillometric reference models and warrants the validation of appropriate equations in clinical applications of oscillometry to avoid diagnostic errors.Our scoping review on adult oscillometric reference equations describes divergence in model construction and variations between the same population-based equations, thus warranting careful selection of oscillometric reference values in clinical practice. https://bit.ly/38a0xwn