RT Journal Article
SR Electronic
T1 No smoke without fire: the impact of cigarette smoking on the immune control of tuberculosis
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 210252
DO 10.1183/16000617.0252-2021
VO 31
IS 164
A1 Diana H. Quan
A1 Alexander J. Kwong
A1 Philip M. Hansbro
A1 Warwick J. Britton
YR 2022
UL http://err.ersjournals.com/content/31/164/210252.abstract
AB Cigarette smoke (CS) exposure is a key risk factor for both active and latent tuberculosis (TB). It is associated with delayed diagnosis, more severe disease progression, unfavourable treatment outcomes and relapse after treatment. Critically, CS exposure is common in heavily populated areas with a high burden of TB, such as China, India and the Russian Federation. It is therefore prudent to evaluate interventions for TB while taking into account the immunological impacts of CS exposure. This review is a mechanistic examination of how CS exposure impairs innate barrier defences, as well as alveolar macrophage, neutrophil, dendritic cell and T-cell functions, in the context of TB infection and disease.This review provides a mechanistic examination of how cigarette smoke exposure impairs innate and adaptive responses to tuberculosis infection and disease https://bit.ly/3tJba18