RT Journal Article SR Electronic T1 No smoke without fire: the impact of cigarette smoking on the immune control of tuberculosis JF European Respiratory Review JO EUROPEAN RESPIRATORY REVIEW FD European Respiratory Society SP 210252 DO 10.1183/16000617.0252-2021 VO 31 IS 164 A1 Quan, Diana H. A1 Kwong, Alexander J. A1 Hansbro, Philip M. A1 Britton, Warwick J. YR 2022 UL http://err.ersjournals.com/content/31/164/210252.abstract AB Cigarette smoke (CS) exposure is a key risk factor for both active and latent tuberculosis (TB). It is associated with delayed diagnosis, more severe disease progression, unfavourable treatment outcomes and relapse after treatment. Critically, CS exposure is common in heavily populated areas with a high burden of TB, such as China, India and the Russian Federation. It is therefore prudent to evaluate interventions for TB while taking into account the immunological impacts of CS exposure. This review is a mechanistic examination of how CS exposure impairs innate barrier defences, as well as alveolar macrophage, neutrophil, dendritic cell and T-cell functions, in the context of TB infection and disease.This review provides a mechanistic examination of how cigarette smoke exposure impairs innate and adaptive responses to tuberculosis infection and disease https://bit.ly/3tJba18