PT  - JOURNAL ARTICLE
AU  - Quan, Diana H.
AU  - Kwong, Alexander J.
AU  - Hansbro, Philip M.
AU  - Britton, Warwick J.
TI  - No smoke without fire: the impact of cigarette smoking on the immune control of tuberculosis
AID  - 10.1183/16000617.0252-2021
DP  - 2022 Jun 30
TA  - European Respiratory Review
PG  - 210252
VI  - 31
IP  - 164
4099  - http://err.ersjournals.com/content/31/164/210252.short
4100  - http://err.ersjournals.com/content/31/164/210252.full
SO  - EUROPEAN RESPIRATORY REVIEW2022 Jun 30; 31
AB  - Cigarette smoke (CS) exposure is a key risk factor for both active and latent tuberculosis (TB). It is associated with delayed diagnosis, more severe disease progression, unfavourable treatment outcomes and relapse after treatment. Critically, CS exposure is common in heavily populated areas with a high burden of TB, such as China, India and the Russian Federation. It is therefore prudent to evaluate interventions for TB while taking into account the immunological impacts of CS exposure. This review is a mechanistic examination of how CS exposure impairs innate barrier defences, as well as alveolar macrophage, neutrophil, dendritic cell and T-cell functions, in the context of TB infection and disease.This review provides a mechanistic examination of how cigarette smoke exposure impairs innate and adaptive responses to tuberculosis infection and disease https://bit.ly/3tJba18