RT Journal Article
SR Electronic
T1 State-of-the-art review of lung imaging in cystic fibrosis with recommendations for pulmonologists and radiologists from the “iMAging managEment of cySTic fibROsis” (MAESTRO) consortium
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 210173
DO 10.1183/16000617.0173-2021
VO 31
IS 163
A1 Pierluigi Ciet
A1 Silvia Bertolo
A1 Mirco Ros
A1 Rosaria Casciaro
A1 Marco Cipolli
A1 Stefano Colagrande
A1 Stefano Costa
A1 Valeria Galici
A1 Andrea Gramegna
A1 Cecilia Lanza
A1 Francesca Lucca
A1 Letizia Macconi
A1 Fabio Majo
A1 Antonella Paciaroni
A1 Giuseppe Fabio Parisi
A1 Francesca Rizzo
A1 Ignazio Salamone
A1 Teresa Santangelo
A1 Luigia Scudeller
A1 Luca Saba
A1 Paolo Tomà
A1 Giovanni Morana
YR 2022
UL http://err.ersjournals.com/content/31/163/210173.abstract
AB Objective Imaging represents an important noninvasive means to assess cystic fibrosis (CF) lung disease, which remains the main cause of morbidity and mortality in CF patients. While the development of new imaging techniques has revolutionised clinical practice, advances have posed diagnostic and monitoring challenges. The authors aim to summarise these challenges and make evidence-based recommendations regarding imaging assessment for both clinicians and radiologists.Study design A committee of 21 experts in CF from the 10 largest specialist centres in Italy was convened, including a radiologist and a pulmonologist from each centre, with the overall aim of developing clear and actionable recommendations for lung imaging in CF. An a priori threshold of at least 80% of the votes was required for acceptance of each statement of recommendation.Results After a systematic review of the relevant literature, the committee convened to evaluate 167 articles. Following five RAND conferences, consensus statements were developed by an executive subcommittee. The entire consensus committee voted and approved 28 main statements.Conclusions There is a need for international guidelines regarding the appropriate timing and selection of imaging modality for patients with CF lung disease; timing and selection depends upon the clinical scenario, the patient's age, lung function and type of treatment. Despite its ubiquity, the use of the chest radiograph remains controversial. Both computed tomography and magnetic resonance imaging should be routinely used to monitor CF lung disease. Future studies should focus on imaging protocol harmonisation both for computed tomography and for magnetic resonance imaging. The introduction of artificial intelligence imaging analysis may further revolutionise clinical practice by providing fast and reliable quantitative outcomes to assess disease status. To date, there is no evidence supporting the use of lung ultrasound to monitor CF lung disease.There is a need for international guidelines regarding the appropriate timing and selection of imaging modality for patients with cystic fibrosis lung disease. https://bit.ly/3HwjUvG