RT Journal Article
SR Electronic
T1 The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 210218
DO 10.1183/16000617.0218-2021
VO 31
IS 163
A1 Melkie, Solomon Tibebu
A1 Arias, Lilibeth
A1 Farroni, Chiara
A1 Jankovic Makek, Mateja
A1 Goletti, Delia
A1 Vilaplana, Cristina
YR 2022
UL https://publications.ersnet.org//content/31/163/210218.abstract
AB Tuberculosis (TB) is still responsible for the deaths of >1 million people yearly worldwide, and therefore its correct diagnosis is one of the key components of any TB eradication programme. However, current TB diagnostic tests have many limitations, and improved diagnostic accuracy is urgently needed. To improve the diagnostic performance of traditional serology, a combination of different Mycobacterium tuberculosis (MTB) antigens and different antibody isotypes has been suggested, with some showing promising performance for the diagnosis of active TB. Given the incomplete protection conferred by bacille Calmette–Guérin (BCG) vaccination against adult pulmonary TB, efforts to discover novel TB vaccines are ongoing. Efficacy studies from advanced TB vaccines designed to stimulate cell-mediated immunity failed to show protection, suggesting that they may not be sufficient and warranting the need for other types of immunity. The role of antibodies as tools for TB therapy, TB diagnosis and TB vaccine design is discussed. Finally, we propose that the inclusion of antibody-based TB vaccines in current clinical trials may be advisable to improve protection.Despite being controversial, antibodies could play a role in the diagnosis of active TB, LTBI and treatment response monitoring. Antibodies could also help when administered as passive transfer and in the protection generated by new TB vaccine candidates. https://bit.ly/3tgEKeP