RT Journal Article
SR Electronic
T1 Management of <em>Mycobacterium avium</em> complex and <em>Mycobacterium abscessus</em> pulmonary disease: therapeutic advances and emerging treatments
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 210212
DO 10.1183/16000617.0212-2021
VO 31
IS 163
A1 Kartik Kumar
A1 Charles L. Daley
A1 David E. Griffith
A1 Michael R. Loebinger
YR 2022
UL http://err.ersjournals.com/content/31/163/210212.abstract
AB Nontuberculous mycobacterial pulmonary disease (NTM-PD) remains a challenging condition to diagnose and treat effectively. Treatment of NTM-PD is prolonged, frequently associated with adverse effects and has variable success. In this review, we consider the factors influencing clinicians when treating NTM-PD and discuss outcomes from key studies on the pharmacological management of Mycobacterium avium complex pulmonary disease and M. abscessus pulmonary disease. We highlight issues relating to treatment-related toxicity and provide an overview of repurposed and emerging therapies for NTM-PD.Despite advances in treatment regimens for nontuberculous mycobacterial pulmonary disease, significant challenges remain. Repurposed and emerging therapies may hold promise. https://bit.ly/3IBPh9q