RT Journal Article
SR Electronic
T1 Epigenetics and sarcoidosis
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 210076
DO 10.1183/16000617.0076-2021
VO 30
IS 160
A1 Iain R. Konigsberg
A1 Lisa A. Maier
A1 Ivana V. Yang
YR 2021
UL http://err.ersjournals.com/content/30/160/210076.abstract
AB Epigenetic modifications are emerging as important regulatory mechanisms of gene expression in lung disease, given that they are influenced by environmental exposures and genetic variants, and that they regulate immune and fibrotic processes. In this review, we introduce these concepts with a focus on the study of DNA methylation and histone modifications and discuss how they have been applied to lung disease, and how they can be applied to sarcoidosis. This information has implications for other exposure and immunologically mediated lung diseases, such as chronic beryllium disease, hypersensitivity pneumonitis, and asbestosis.In this review, we summarise recent findings relating to epigenetic modifications in lung disease with a focus on sarcoidosis, and propose guidelines and rationale for future epigenomic studies of sarcoidosis https://bit.ly/3d7Is1B