RT Journal Article
SR Electronic
T1 Cystic fibrosis-related diabetes and lung disease: an update
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 200293
DO 10.1183/16000617.0293-2020
VO 30
IS 159
A1 Prentice, Bernadette J.
A1 Jaffe, Adam
A1 Hameed, Shihab
A1 Verge, Charles F.
A1 Waters, Shafagh
A1 Widger, John
YR 2021
UL http://err.ersjournals.com/content/30/159/200293.abstract
AB The development of cystic fibrosis-related diabetes (CFRD) often leads to poorer outcomes in patients with cystic fibrosis including increases in pulmonary exacerbations, poorer lung function and early mortality. This review highlights the many factors contributing to the clinical decline seen in patients diagnosed with CFRD, highlighting the important role of nutrition, the direct effect of hyperglycaemia on the lungs, the immunomodulatory effects of high glucose levels and the potential role of genetic modifiers in CFRD.Cystic fibrosis (CF)-related diabetes remains one of the most important comorbidities for patients with CF because of the impact on lung function and mortality. There are numerous factors in addition to infection that contribute to the negative effects of CF-related diabetes. https://bit.ly/3nSPFW6