RT Journal Article
SR Electronic
T1 Asthma-COPD overlap: current understanding and the utility of experimental models
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 190185
DO 10.1183/16000617.0185-2019
VO 30
IS 159
A1 Xiaofan Tu
A1 Chantal Donovan
A1 Richard Y. Kim
A1 Peter A.B. Wark
A1 Jay C. Horvat
A1 Philip M. Hansbro
YR 2021
UL http://err.ersjournals.com/content/30/159/190185.abstract
AB Pathological features of both asthma and COPD coexist in some patients and this is termed asthma-COPD overlap (ACO). ACO is heterogeneous and patients exhibit various combinations of asthma and COPD features, making it difficult to characterise the underlying pathogenic mechanisms. There are no controlled studies that define effective therapies for ACO, which arises from the lack of international consensus on the definition and diagnostic criteria for ACO, as well as scant in vitro and in vivo data. There remain unmet needs for experimental models of ACO that accurately recapitulate the hallmark features of ACO in patients. The development and interrogation of such models will identify underlying disease-causing mechanisms, as well as enabling the identification of novel therapeutic targets and providing a platform for assessing new ACO therapies. Here, we review the current understanding of the clinical features of ACO and highlight the approaches that are best suited for developing representative experimental models of ACO.Understanding the pathogenesis of asthma-COPD overlap is critical for improving therapeutic approaches. We present current knowledge on asthma-COPD overlap and the requirements for developing an optimal animal model of disease. https://bit.ly/3lsjyvm