PT  - JOURNAL ARTICLE
AU  - Higham, Andrew
AU  - Mathioudakis, Alexander
AU  - Vestbo, Jørgen
AU  - Singh, Dave
TI  - COVID-19 and COPD: a narrative review of the basic science and clinical outcomes
AID  - 10.1183/16000617.0199-2020
DP  - 2020 Dec 31
TA  - European Respiratory Review
PG  - 200199
VI  - 29
IP  - 158
4099  - http://err.ersjournals.com/content/29/158/200199.short
4100  - http://err.ersjournals.com/content/29/158/200199.full
SO  - EUROPEAN RESPIRATORY REVIEW2020 Dec 31; 29
AB  - The 2019 coronavirus disease (COVID-19) pandemic is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Clinical outcomes, including mortality, are worse in males, older individuals and patients with comorbidities. COPD patients are included in shielding strategies due to their susceptibility to virus-induced exacerbations, compromised pulmonary function and high prevalence of associated comorbidities. Using evidence from basic science and cohort studies, this review addresses key questions concerning COVID-19 and COPD. First, are there mechanisms by which COPD patients are more susceptible to SARS-CoV-2 infection? Secondly, do inhaled corticosteroids offer protection against COVID-19? And, thirdly, what is the evidence regarding clinical outcomes from COVID-19 in COPD patients? This up-to-date review tackles some of the key issues which have significant impact on the long-term outlook for COPD patients in the context of COVID-19.This up-to-date review tackles some of the key issues which have significant impact on the long-term outlook for COPD patients in the context of COVID-19 https://bit.ly/36PKzEO