PT - JOURNAL ARTICLE AU - Ingrid A. Cox AU - Nicolas Borchers Arriagada AU - Barbara de Graaff AU - Tamera J. Corte AU - Ian Glaspole AU - Stella Lartey AU - E. Haydn Walters AU - Andrew J. Palmer TI - Health-related quality of life of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis AID - 10.1183/16000617.0154-2020 DP - 2020 Dec 31 TA - European Respiratory Review PG - 200154 VI - 29 IP - 158 4099 - http://err.ersjournals.com/content/29/158/200154.short 4100 - http://err.ersjournals.com/content/29/158/200154.full SO - EUROPEAN RESPIRATORY REVIEW2020 Dec 31; 29 AB - Idiopathic pulmonary fibrosis (IPF) is one of the most common forms of interstitial lung disease presenting in persons 50 years and older. Through a comprehensive review of available studies, we aimed to assess health-related quality of life (HRQoL) of people living with IPF and the instruments used in this assessment.Searches were conducted up to May, 2020. Quality appraisal and data extraction were performed using pre-designed forms. Narrative synthesis approach was used to report results of the systematic review and a random effects model was used for the meta-analysis. A leave-one-out sensitivity analysis was performed, and a trim and fill method was used to assess publication bias.The review included 134 studies. The most used instruments to measure HRQoL were St George's Respiratory Questionnaire (SGRQ), Short Form 36 (SF36) and EuroQoL (EQ5D). Standardised mean scores (95% confidence interval) for these instruments were as follows: SGRQ total score: 44.72 (42.21–47.22); SF36 physical component score (PCS): 37.00 (34.74–39.26) SF36 mental component score (MCS): 50.18 (48.41–51.95); King's Brief Interstitial Lung Disease questionnaire total score: 58.38 (55.26–61.51); and EQ5D utility: 0.73 (0.68–0.79). Analysis of standardised means for both SGRQ and SF36 demonstrated worse scores in physical health domains as compared to mental health domains.This systematic review confirms that IPF negatively affected HRQoL, mostly impacting the physical health domains. This study also demonstrated that a diverse number of instruments are used to evaluate HRQoL. In view of this diversity, a standardised approach to measurement of HRQoL for IPF is important to ensure that comparisons made are reliable.This study established that a wide variety of instruments are used to evaluate HRQoL in IPF and suggests that to improve comparability across studies, a standardised approach to the measurement of HRQoL is important https://bit.ly/2XJSApz