PT - JOURNAL ARTICLE AU - Christopher M. Kniese AU - Ali I. Musani TI - Bronchoscopic treatment of inoperable nonsmall cell lung cancer AID - 10.1183/16000617.0035-2020 DP - 2020 Dec 31 TA - European Respiratory Review PG - 200035 VI - 29 IP - 158 4099 - http://err.ersjournals.com/content/29/158/200035.short 4100 - http://err.ersjournals.com/content/29/158/200035.full SO - EUROPEAN RESPIRATORY REVIEW2020 Dec 31; 29 AB - Patients with unresectable lung cancer range from those with early-stage or pre-invasive disease with comorbidities that preclude surgery to those with advanced stage disease in whom surgery is contraindicated. In such cases, a multidisciplinary approach to treatment is warranted, and may involve medical specialties including medical oncology, radiation oncology and interventional pulmonology. In this article we review bronchoscopic approaches to surgically unresectable lung cancer, including photodynamic therapy, brachytherapy, endoscopic ablation techniques and airway stenting. Current and past literature is reviewed to provide an overview of the topic, including a highlight of potential emerging approaches.PDT and EBBT may be effective options for early-stage NSCLC. PDT, EBBT, debulking and stenting may be offered to patients receiving definitive treatment or for palliation. Respiratory failure is not a contraindication to therapeutic bronchoscopy. https://bit.ly/2SmhtEQ