TY - JOUR T1 - Mitochondrial dysfunction in lung ageing and disease JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW DO - 10.1183/16000617.0165-2020 VL - 29 IS - 157 SP - 200165 AU - Suzanne M. Cloonan AU - Kihwan Kim AU - Pauline Esteves AU - Thomas Trian AU - Peter J. Barnes Y1 - 2020/09/30 UR - http://err.ersjournals.com/content/29/157/200165.abstract N2 - Mitochondrial biology has seen a surge in popularity in the past 5 years, with the emergence of numerous new avenues of exciting mitochondria-related research including immunometabolism, mitochondrial transplantation and mitochondria-microbe biology. Since the early 1960s mitochondrial dysfunction has been observed in cells of the lung in individuals and in experimental models of chronic and acute respiratory diseases. However, it is only in the past decade with the emergence of more sophisticated tools and methodologies that we are beginning to understand how this enigmatic organelle regulates cellular homeostasis and contributes to disease processes in the lung. In this review, we highlight the diverse role of mitochondria in individual lung cell populations and what happens when these essential organelles become dysfunctional with ageing and in acute and chronic lung disease. Although much remains to be uncovered, we also discuss potential targeted therapeutics for mitochondrial dysfunction in the ageing and diseased lung.We provide an up-to-date synopsis of the diverse nature of the mitochondrion in maintaining cellular homeostasis in an array of lung cell types and what happens when these pathways become dysfunctional with ageing and with acute or chronic lung disease. https://bit.ly/30jNKjZ ER -