PT  - JOURNAL ARTICLE
AU  - Zheng, Xiang
AU  - Mansouri, Siavash
AU  - Krager, Annika
AU  - Grimminger, Friedrich
AU  - Seeger, Werner
AU  - Pullamsetti, Soni S.
AU  - Wheelock, Craig E.
AU  - Savai, Rajkumar
TI  - Metabolism in tumour-associated macrophages: a <em>quid pro quo</em> with the tumour microenvironment
AID  - 10.1183/16000617.0134-2020
DP  - 2020 Sep 30
TA  - European Respiratory Review
PG  - 200134
VI  - 29
IP  - 157
4099  - http://err.ersjournals.com/content/29/157/200134.short
4100  - http://err.ersjournals.com/content/29/157/200134.full
SO  - EUROPEAN RESPIRATORY REVIEW2020 Sep 30; 29
AB  - Lung cancer is the leading cause of death from cancer worldwide. Recent studies demonstrated that the tumour microenvironment (TME) is pivotal for tumour progression, providing multiple targeting opportunities for therapeutic strategies. As one of the most abundant stromal cell types in the TME, tumour-associated macrophages (TAMs) exhibit high plasticity. Malignant cells alter their metabolic profiles to adapt to the limited availability of oxygen and nutrients in the TME, resulting in functional alteration of TAMs. The metabolic features of TAMs are strongly associated with their functional plasticity, which further impacts metabolic profiling in the TME and contributes to tumourigenesis and progression. Here, we review the functional determination of the TME by TAM metabolic alterations, including glycolysis as well as fatty acid and amino acid metabolism, which in turn are influenced by environmental changes. Additionally, we discuss metabolic reprogramming of TAMs to a tumouricidal phenotype as a potential antitumoural therapeutic strategy.Tumour-associated macrophages (TAMs) display a high level of functional plasticity and altered metabolism symbolised by high sensitivity to the surrounding tumour microenvironment. The metabolism of TAMs provides novel therapeutic opportunities to treat cancer. https://bit.ly/31OqHhe